KNOVA is a NIPT screening test that examines placental DNA from your blood to see if there are signs of genetic conditions that could affect your baby’s health
KNOVA covers all conditions screened on standard non-invasive prenatal tests (NIPTs)
KNOVA also screens for severe conditions that are not included on standard NIPTs (identifying 60% more pregnancies with severe genetic conditions compared to standard NIPT)
This includes severe single gene disorders that may be undetectable by ultrasound early in the pregnancy (see key benefit to the right)
Your doctor can order this test for you as early as 10 weeks into your pregnancy, and it only requires a simple blood draw
Results will be available in approximately 10 days from the time the sample is received at our laboratory
KNOVA screens for genetic changes that typically appear in the family for the first time. Since these are “de novo,” there may be no family history for these conditions, and a standard carrier screening typically cannot detect these risks. KNOVA can be used to detect severe conditions as early as 10 weeks into pregnancy, when many risks are still undetectable by ultrasound.
| Category | Targets Analysed | Examples |
|---|---|---|
| Autosomal trisomies | 6 types Trisomy 13*, Trisomy 15, Trisomy 16, Trisomy 18*, Trisomy 21*, Trisomy 22 | Down syndrome Edwards syndrome Patau syndrome |
| Sex chromosome aneuploidies | 4 types 45,X; 47,XXX; 47,XXY; 47,XYY | Turner syndrome Triple X syndrome Klinefelter syndrome |
| Chromosomal microdeletions | 12 microdeletions 1p36 del, 2q33 del, 4p16 del, 5p15 del, 8q23q24 del, 9p del, 11q23q25 del, 15q11.2-q13 del, 17p11.2 del, 18p del, 18q22q23 del, 22q11.2 del, del, 15q11.2-q13 del, 17p11.2 del, 18p del, 18q22q23 del, 22q11.2 del | Angelman syndrome Prader-Willi syndrome Cri-du-Chat syndrome |
| Single gene disorders |
56 genes, associated with 30+ monogenic conditions including: Noonan Spectrum Disorders – typically feature heart defects, short stature, and characteristic facial features BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, RIT1, SHOC2, SOS1, SOS2 Disorders with Multiple Congenital Anomalies – a range of structural abnormalities affecting multiple organ systems CD96, CHD7, EFNB1, GLI3, HDAC8, HNRNPK, KMT2D, NIPBL, NSD1, NSDHL, RAD21, SMC1A, SMC3, SNRPB, SPECC1L, TCF12, TRAF7, ZIC1 Neurological Disorders – can cause developmental delays, intellectual disability, and other neurological issues ASXL1, CDKL5, MECP2, TSC1, TSC2 Skeletal Disorders – affect bone development and growth, may cause fragile bones, abnormal limb or joint formation COL10A1, COL11A1, COL1A1, COL1A2, COL2A1, EBP, ERF, FGFR1, FGFR2, FGFR3, FLNB, FREM1, KAT6B, RUNX2, SKI, SLC25A24, SOX9, TWIST1 Other Severe Disorders |
|
Low Risk:
A low-risk result means that your baby has a very low chance of having one of the conditions tested for by KNOVA. KNOVA is a screening test and is not diagnostic.
What does a high-risk result mean?
High Risk:
A high-risk result means your baby has a higher chance of having one of the conditions tested for by KNOVA. As a screening test, prenatal cfDNA testing identifies pregnancies at high risk for certain conditions. Prenatal cfDNA testing is not diagnostic, and if a high-risk pregnancy is identified, further diagnostic testing (during pregnancy or postnatally) is required to know whether the baby is affected. Decisions about a pregnancy should not be made using the KNOVA test alone. Rather, this test should be used to help identify risk at an early stage.
| Targets Screened | Standard NIPT | KNOVA |
|---|---|---|
| Trisomy 13/18/21 | Yes | Yes |
| Other chromosome abnormalities | No | Yes |
| Microdeletion syndromes | No | Yes |
| Select single gene disorders | No | Yes |
Unfortunately, due to the specific advanced technology used by Fulgent, IVF pregnancies involving egg donors and/or multiple pregnancies (such as twins or triplets) are not eligible for KNOVA screening.
Please note that we are led by a team of highly skilled specialist doctors that offer diagnosis and treatment of complications which may arise in unborn babies. All your scans will be performed by our experienced fetal medicine consultants. We do not offer scans performed by sonographers or fellows. The service we provide by consultants offer screening, diagnosis and management of your pregnancy to the highest standards.
Includes an ultrasound and NIPT test.
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